About the role:

We are looking for an outstanding synthetic chemist to join the Synthesis and Fundamental Chemistry team as a scientist. This unique multi-disciplinary position will focus on the development of novel nucleotides and/or oligonucleotides and processes to enable new or improved internal and customer facing applications. The candidate will work closely with a variety of groups including Molecular Biology, Process Development and Microfluidics. The candidate should have experience working independently in a chemistry laboratory as well as function as an essential part of a cross disciplinary team, bringing a strong initiative to our fast-paced product development efforts.

Individuals applying for this position should be familiar with the design and synthesis of novel nucleotides and/or oligonucleotides, dyes used for imaging applications, experience with the design and synthesis of other novel small molecules, familiar with functionalization of material and surfaces, bioconjugation as well as the scale up and development of novel chemistries for manufacturing. Successful candidates should also have familiarity with handling of biological samples.

What you will be doing:

• Assist in the development of novel chemistries with a clear rationale for their design and associated performance in biochemical assays
• Designing and synthesizing novel nucleotides and/or oligonucleotides for use in biological assays
• Developing a robust method for nucleotides/oligonucleotides purification and QC
• Designing and synthesizing novel dyes for use in imaging applications
• Synthesis, scale up and transfer of mature processes to our synthesis manufacturing team
• Evaluating novel targets with biochemical assays to assess structure activity relationships
• Organize, evaluate, and communicate key findings at project meetings and make recommendations for follow-up studies and prioritization.

To be successful in this role, you will need:

• PhD in chemistry, chemical engineering, or a related field or MS +3 years of experience
• Demonstrated experience with the design and synthesis of complex novel targets
• Relevant laboratory experience in life science applications.
• Desire to be part of a rapidly evolving organization, which requires real-time communication, flexibility, working well with others, and a willingness to learn new techniques and methods.
• Demonstrated ability to analyze and interpret complex data sets and communicate results in a clear and concise manner.
• Demonstrated ability to work in a multi-disciplinary team.
• Experience executing molecular biology assays.

Additionally, we’d like to see:

• Experience in surface chemistry, polymer chemistry, bioconjugation and surface functionalization.
• Familiar with the handling of tissues, cells or other biological samples
• Experience with imaging of biological samples
• Experience in photolithography, next-generation sequencing library preparation, single-cell genomics, or microfluidics.
• Proven research outcomes such as publication in a peer-reviewed journal, patent, presentation in a public forum, or thesis.