Optical Engineer III

10X Genomics

10X Genomics

Other Engineering
Pleasanton, CA, USA
Posted on Monday, December 11, 2023

About the role

The hardware engineering group is responsible for the design, build, and test of 10X’s consumer, and some of it’s internal, instruments from R&D prototypes to manufacturing pilot builds. Most recently our group has shipped CytAssist and the industry leading Xenium Analyzer. We are currently looking for an outstanding Optical Engineer to join our optical team to take a lead role in developing and prototyping both verification / validation tests of formal DIRs and tests, fixtures, and analysis scripts to evaluate, troubleshoot, and improve the design, assembly, and operation of optical, optomechanical and optofluidic modules while working closely with hardware and firmware engineers.

Ideal candidates will be independent operators that are as comfortable wielding a socket wrench as fine tuning the alignment of high performance lens assemblies. Applicants should have a love of tinkering and hands-on-work while also enjoying data analysis.

What you will be doing

  • Designing and building complex, state-of-the-art test fixtures and measurement devices such as wavefront interferometers and high sensitivity fluorimeters
  • Building early instrument prototypes made of custom and off-the-shelf parts by using CAD models and common sense for the lack of yet to be written assembly, alignment, and test procedures
  • Finding hardware design and manufacturing bugs and working with design engineers and parts vendors to resolve them.
  • Troubleshooting various issues in tested and operating modules: misalignment, contamination, vibration, leaks, etc.
  • Collecting and analyzing data to characterize the module or the whole instrument performance: emission and transmission spectra, signal intensities and time traces, images and associated metrics for their analyses.
  • Writing some python code to prototype automation of optomechanics, such as control of motion stages, cameras, and illumination assemblies, and to process images for various kinds of tests and calibrations.

To be successful, you will need

  • A bachelor's or higher degree in an engineering or physical sciences field
  • Experience with
    • Light sources and beam shaping: e.g. lasers, LEDs, SLDs, etc.
    • Light detectors: e.g. sCMOS, CCD, photodiodes, etc.
    • Optical fibers: properties, light coupling, collimation, and general alignment.
    • Measurement devices: e.g. power meters, spectrometers, oscilloscopes etc.
    • Optical components: e.g. mirrors, lenses, prisms, filters, etc.
    • Mechanical components: kinematic, linear, and rotary stages.
  • Good theoretical knowledge of geometrical optics.
  • Good optical laboratory skills: assembly, cleaning, alignment of delicate and precise optical components.
  • Experience with optical metrology methods for component and system test, verification and validation.
  • Proficient in Python (preferred) or similar numerical analysis language / environment.

Nice to have skills & background

  • Theoretical knowledge of image formation in high numerical aperture imaging systems.
  • Knowledge of wave optics and Fourier optics.
  • Understanding of optical aberration theory and the characterization aberrations in practice for high NA systems.
  • Experience with image processing.
  • Optical CAD (e.g. ZEMAX) experience.
  • Mechanical CAD (e.g. SolidWorks) experience.
  • Familiarity with rapid prototyping (e.g. 3D printing).
  • Working knowledge of git version control.
  • Comfort disassembling and reassembling complex instruments and devices
  • Expert ability to use a ball driver.

Below is the base pay range for this full time position. The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience. At 10x, base pay is also just one component of the Company’s total compensation package. This role is also eligible for 10x’s equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. Your 10x recruiter can share more about the Company’s total compensation package during the hiring process.

Pay Range
$131,400$160,600 USD

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.