Sr. Computational Biologist, Spatial Biology

10X Genomics

10X Genomics

Pleasanton, CA, USA
Posted on Thursday, March 7, 2024

About the Role:

We are on a quest to find a pioneering engineer to join our Computational Biology group, a team at the forefront of developing single-cell and spatial genomic assays. This role is crucial for advancing our in-situ platforms and assays, which have revolutionized how researchers explore complex biological systems across various fields such as cancer biology, immunology, and neuroscience. The ideal candidate will possess a deep understanding of statistical modeling, numerical optimization algorithms, and the practical application of these skills, striking the right balance between classical and modern approaches. You should be a self-starter, capable of independent thinking, and thrive in a highly collaborative, interdisciplinary, and fast-paced environment. You have experience working on large code repositories.

What You Will Be Doing:

  • Implementing signal processing, pattern matching, and model fitting pipelines to analyze large multidimensional and multimodal datasets to improve our spatial and in-situ assays.
  • Creating analytical models or simulations of the data generating process to elucidate and communicate the trade-offs involved in system design, data quality and algorithms.
  • Optimizing algorithms leveraging CPU/GPU architecture to enhance data processing capabilities.

To Be Successful in This Role, You Will Need:

  • PhD, MS, or equivalent industry experience in a quantitative field such as computational biology, computer science, physics, mathematics, statistics, or electrical engineering.
  • Proficient programming skills in Python and compiled languages (e.g. C/C++, Rust, etc), with a solid background in deploying code on GPUs.
  • The ability to research, adapt, and innovate upon existing methods from literature and libraries, transforming them into well-architected, efficient code.

Additional Desirable Skills to Have:

  • Exposure to multiplexed imaging and sequencing technologies, and spatial biology.
  • A creative problem-solving approach that prioritizes extracting maximum performance from code, while navigating the imperfections inherent in real-world data and maintaining theoretical integrity.
  • Knowledge of sequence alignment models, information theory, inverse problems.

This role is tailored for an individual who is not only technically proficient but also possesses a strategic mindset, capable of driving projects forward in a dynamic research and development landscape. If you are passionate about leveraging computational power to unlock the mysteries of biology at an unprecedented scale, we encourage you to apply.

Below is the base pay range for this full time position. The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience. At 10x, base pay is also just one component of the Company’s total compensation package. This role is also eligible for 10x’s equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. Your 10x recruiter can share more about the Company’s total compensation package during the hiring process.

Pay Range
$174,000$236,000 USD

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.