Encoded Therapeutics Inc. is a biotechnology company advancing precision medicines for a broad range of genetic disorders. Our mission is to unlock new opportunities for viral gene therapy through genomics-driven discovery. We focus on delivering life-changing advances for individuals with genetic disorders not addressable with current approaches. For more information, please visit www.Encoded.com.

Position details

Encoded is seeking a Scientist to play a leading role in our Downstream Process Development group. The candidate will apply technical knowledge and experience to design and improve unit operations for purification of Encoded’s AAV-based therapeutic candidates. The Downstream Process Development team operates with the mission to develop high-performing, scalable, robust, and cost-effective viral vector purification strategies for use in clinical manufacturing. The candidate will collaborate closely with other members of Process Development, as well as MSAT, Research Vector Production, and Analytical Development teams. Development of our platform process will include innovation and optimization of harvest clarification, chromatography, and tangential-flow filtration unit operations, as well as process transfer activities. As programs advance into clinical development and toward commercialization, expanded process knowledge will be applied toward support of regulatory filings.

This is a unique opportunity to join a high-performing team that is at the forefront of Gene Therapy process development. The successful candidate will build upon their deep knowledge base and considerable experience to become an expert in the field. By enhancing our ability to manufacture rAAV vectors, our work will directly contribute to enabling gene therapies for broader and more challenging indications.

Workplace Model: Onsite

Responsibilities

• Design, carry out, and interpret purification studies necessary to support pre-clinical development for rAAV-based gene therapies
• Provide technical expertise in purification technologies and protein chemistry, applied toward of AAV viral vectors
• Operate chromatography (affinity, ion-exchange, multi-modal) and filtration (tangential flow, depth filtration, virus retentive) unit operations for production of preclinical rAAV drug substance
• Contribute to development of long-term PD platform strategy, including initiatives to improve process understanding, product quality, step yields, and cycle times
• Collaborate across broader PD, AD, and MSAT departments for study, scaling, and implementation of new process technologies
• Author technical reports and contribute to regulatory documents
• Assist with group-level planning and conduct initiatives to improve workflows
• Management of 2 direct reports
• May include approximately 20% remote work, with flexibility based on project needs