Scientist, Research & Development

About Moonlight Bio:

Moonlight Bio is a Seattle-based, preclinical stage biotech company pioneering the development of cutting-edge cell therapies for the treatment of cancer. Our team is comprised of highly collaborative individuals who are passionate about designing innovative technologies and drug candidates with the potential to transform the lives of cancer patients. Our teams engage across the entire drug development landscape, pursuing opportunities in discovery & mechanistic research, component design & screening, preclinical modeling, process & analytical development, translational & correlative studies, innovative clinical development strategies, and partnerships necessary to enable and transform our core technologies into groundbreaking cell-based medicines.

Roles & Responsibilities:

We are seeking a highly motivated and skilled Scientist with a strong background in T cell engineering to join our team. This position is primarily a lab-based role, working on-site in our office and laboratory in Seattle’s Eastlake neighborhood, and will be reporting to the Director, Research & Development. This role will develop research strategies that span the design and assessment of innovative potency enhanced CAR and TCR based T cell therapies. The role will involve discovering and assessing diverse potency enhancement components and strategies that support product conceptualization and development. The ideal candidate will be an outstanding scientist with experience in the cell and gene therapy field, who has demonstrated scientific excellence, a strong sense of curiosity, and a proven capacity for working collaboratively with a ‘team science’ mindset to tackle the myriad of challenges that come with developing cell therapies.

A typical day may involve the following activities:

· Designing, generating, and assessing (in vitro and in vivo) novel CAR and TCR architectures.

· Developing in vitro and/or in vivo screening platforms to enable discovery and assessment of potency enhancement strategies.

· Compiling, analyzing, and presenting data to various audiences, including executive leadership, advisory boards, founders, and external collaborators.

· Serving on cross-functional project teams and actively engaging in team discussions.

We are looking for candidates who possess the following qualifications:

· PhD degree in protein engineering, genetics, immunology, or related disciplines

• Established knowledge and technical proficiency in engineered T cell biology and related in vitro and in vivo characterization and functional assessments, with preferential experience in utilizing 1) viral vector design for targeted T cell engineering; 2) various protein modeling tools (e.g., AlphaFold, PyMol) for protein design; 3) in vitro and/or in vivo screening platforms for functional assessment of potency enhanced T cells; and 4) gene editing tools for T cell engineering.
• Demonstrated track record of producing high quality scientific results as an individual contributor.
• Excellent organization and communication skills (written and oral) to meet deadlines and balance time and effort across multiple workstreams.
• Enthusiasm for creative, solution-oriented thinking and working collaboratively in a team environment.

What you should know:

· The base pay range for this position at commencement of employment is expected to be between $115,000-$135,000.

· The base pay offered may vary depending on a variety of individualized factors, including the relevance, and years, of the applicant’s experience, job-related knowledge, skill set, certifications, qualifications, and/or professional licenses held, and market location.

· Full time employees (and their eligible dependents) will be eligible for employee benefits including PTO, medical, dental, and vision plans from the first day of employment. Further, Moonlight supports its team members in pursuing certifications, conferences, and training relevant to their roles.

At Moonlight Bio, we are committed to providing equal employment opportunities to all employees and applicants without regard to characteristics and statuses protected under applicable federal, state, and local laws. Applicants must be authorized to work in the United States. Moonlight Bio will not sponsor applicants for work visas.

Join us at Moonlight Bio and contribute to groundbreaking research that has the potential to create innovative and powerful new cancer therapies! With our collaborative, team-centric R&D approach, and our dedication to professional development, you’ll have the opportunity to make a meaningful impact on patients’ lives while advancing your career in the dynamic field of cell therapy.

Please apply directly within LinkedIn or submit your resume/CV and cover letter to careers@moonlightbio.us